Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TNFR2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
No hypothermia, hyperglycemia or coma; ↓ vascular permeability in brain and lung; similar thrombocytopenia and lung weight; similar leukocyte sequestration in brain; ↓ macrophage accumulation and similar pRBC sequestration in alveolar capillaries; similar TNF-a, CD40 and ICAM-1 mRNA expression in brain and spleen; similar TNF-a, CD40 and ↓ ICAM-1 in lung; insulin sensitive (mice died of hypoglycemia after insulin injection)
Refs:
Piguet et al., 2002, Lab Invest
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