TNFR1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNFR1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
Tg + soluble TNFR1
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (80%)
Pathology (EG): 
CM (20-30% in high expressor mice); CM (100% in low expressor mice)
Parasitemia (EG vs Con): 
similar
Additional phenotypes (EG vs Con): 
Prolonged survival in high-expressor mice (~2 weeks); no neurological symptoms
Refs: 
Garcia et al., 1995, Eur J Immunol