Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Tg + soluble TNFR1
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (20-30% in high expressor mice); CM (100% in low expressor mice)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival in high-expressor mice (~2 weeks); no neurological symptoms
Refs:
Garcia et al., 1995, Eur J Immunol
Hyperlink: