Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TNFR1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
CM
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Similar TNF-a, CD40 and ICAM-1 in brain; ↓ vascular leakage in brain and lung; similar BBB breakdown, macrophage accumulation in brain, hyperglycemia, insulin resistance, hypothermia, edema, thrombocytopenia and lung weight; enlarged basement membrane of brain capillaries in KO mice
Refs:
Piguet et al., 2002, Lab Invest
Hyperlink: