Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
N.I.
Mouse genetic background (Con):
C57BL/6 x 129
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TNFR1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (78%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Similar neurologic symptoms and lung pathology; similar serum IFN-g and TNF-a; similar ICAM-1 endothelial expression in brain and lung
Refs:
Lucas et al., 1997, J Neuroimmunol
Hyperlink: