Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TNFR1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (78%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Similar neurologic symptoms; similar serum IFN-g, TNF-a and sTNFR2; similar ICAM-1 expression on endothelial cells and sequestering leukocytes in the brain; induction of ICAM-1 expression in MVEC through binding of membrane-bound mTNF-a (but not soluble mTNF or membrane-bound hTNF) with TNFR2
Refs:
Lucas et al., 1997, Eur J Immun
Hyperlink: