TNFR1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNFR1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6 x 129
Level of backcrossing: 
Mixed background (50%)
Experimental treatment group (EG): 
TNFR1 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (90%)
Pathology (EG): 
CM (78%)
Parasitemia (EG vs Con): 
similar
Additional phenotypes (EG vs Con): 
Similar neurologic symptoms; similar serum IFN-g, TNF-a and sTNFR2; similar ICAM-1 expression on endothelial cells and sequestering leukocytes in the brain; induction of ICAM-1 expression in MVEC through binding of membrane-bound mTNF-a (but not soluble mTNF or membrane-bound hTNF) with TNFR2
Refs: 
Lucas et al., 1997, Eur J Immun