Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
10^3
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rHu-TNF-a (↑ dose)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
TNF toxicity
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Died 24 h after injection; hypothermia, brain petechial hemorrhages; ↑ kidney, lung and liver pathology
Refs:
Curfs et al., 1993, Parasitology
Hyperlink: