Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
rHu-TNF-a or rMu-TNF-a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
No neurological symptoms; no petechial hemorrhages or edema in brain; no monocytes adherence in cerebral vessels; developed hypoglycaemia and midzonal liver necrosis
Refs:
Clark et al., 1992, Am J Pathol
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