Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-TNF-a (Mab)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar iNOS mRNA expression in spleen 7 days p.i.; partial ↓ NO3- levels in serum 7 days p.i.; ↓ spleen weight 7 days p.i.
Refs:
Jacobs et al. 1996, Infect Immun
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