Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-TNF-a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (79%)
Pathology (EG):
CM (6,6%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-3 weeks); no neurological symptoms; no macrophage accumulation in brain; ↓ macrophage accumulation in spleen and lymph nodes; similar parasite-specific Ab response
Refs:
Grau et al., 1987, Science
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