Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a/ LT-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Sv/Ev x C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TNF-a -/- x LT-a -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); no neurological symptoms; similar anemia; slightly ↑ leukocytosis; no leukocyte accumulation in brain; ↓ ICAM-1 + CD11b in brain; ↓ serum NO; ↓ IFN-g and no IL-12 , IL-10 and IL-4 mRNA expression in the brain; similar IFN-g, IL-12, IL-10 and no IL-4 mRNA expression in the spleen
Refs:
Rudin et al., 1997, Am J Pathol
Hyperlink: