TNF-a

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a
Plasmodium strain: 
Plasmodium yoelii 17XL
pRBC infection titer: 
10^5 or 10^6
Mouse genetic background (Con): 
C57BL/6 x 129
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
TNF-a -/-
Lethal infection (Con): 
Lethality dependent on parasite dosis, no difference between WT and KO mice
Lethal infection (EG): 
Lethality dependent on parasite dosis, no difference between WT and KO mice
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
No clearance in 25 days
Additional phenotypes (EG vs Con): 
N.I.
Refs: 
Shear et al., 1998, Am J Trop Med Hyg