Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
10^5 or 10^6
Mouse genetic background (Con):
C57BL/6 x 129
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TNF-a -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased peak and delayed clearance
Additional phenotypes (EG vs Con):
N.I.
Refs:
Shear et al., 1998, Am J Trop Med Hyg
Hyperlink: