TNF-a

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Pure strain (100%)
Experimental treatment group (EG): 
TNF-a -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
Anemia
Pathology (EG): 
Anemia
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar anemia, serum IFN-g and Ig titers; ↓ serum TNF-a
Refs: 
Clark et al., 2007, Parasite Immunol