Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
TNF-a -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar anemia, serum IFN-g and Ig titers; ↓ serum TNF-a
Refs:
Clark et al., 2007, Parasite Immunol
Hyperlink: