Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei (N.I.)
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
TNF-a -/-
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar number of CD11c+ DC in the spleen; ↓ expression of MHC II, CD80 and CD86 by splenic CD11c+ DC; CD11c+ DC were better at initiation of proliferation of OTII T cells; ↑ IL-12 secreting DC in the spleen
Refs:
Wykes et al., 2007, J Immunol
Hyperlink: