TNF-a

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
TNF-a
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6J
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
TNF-a -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM
Pathology (EG): 
CM
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar neurologic symptoms; similar levels of [31P]-containing metabolites (phosphomonoesters (PME), inorganic phosphate (Pi), phosphocreatinine (PCr), Pi:b-ATP, Pi:PCr) and ↑ levels (normal values) of b-ATP and PCr:PME in brain 6-7 days p.i.; ↓ GABA, and aspartate, ↑ glutamine and NAA, and similar alanine, lactate and glutamate metabolite pool sizes in brain (compared with uninfected TNF-a -/- mice); similar brain net flux of 13C from D-[1-13C]glucose into metabolic intermediates associated with Krebs cycle (↓ compared to uninfected TNF-a -/- mice), except for Asp C3 and Lac C3 which was not ↓ and Ala C3 which did not change upon infection
Refs: 
Parekh et al., 2006, Int J Parasitol