Molecular group:
Cytokines and receptors
Molecule/Cell:
TNF-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
Backcrossed for at least 10 generations
Experimental treatment group (EG):
TNF-a -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
similar
Additional phenotypes (EG vs Con):
Similar neurologic symptoms: similar ischemic brain damage, brain swelling, edema and vascular blood flow perturbations; no anemia (cfr. WT); similar perforin+CD8+, CD54+CD8+ and CD69+CD8+ T cells in brain; similar lung pathology and edema; similar thickening of alveolar septae
Refs:
Togbe et al., 2008, PLoS One
Hyperlink: