Molecular group:
Cytokines and receptors
Molecule/Cell:
SOCS1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
SOCS1 +/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (80%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar neurological symptoms
Refs:
Bullen et al., 2003, Parasite Immunol
Hyperlink: