Molecular group:
Cytokines and receptors
Molecule/Cell:
IRF-1/IL-12
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IRF-1 -/- + rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak
Additional phenotypes (EG vs Con):
Earlier death (days); IL-10 mRNA expression was similar on day 4 and unsignificantly ↓ on day 8 p.i. in the liver, ↑ at day 4 and similar at day 8 p.i. in the spleen and similar 8 days p.i. in the kidneys; TNF-a mRNA expression was undetectable throughout the course of infection
Refs:
Tan et al., 1999, Infect Immun
Hyperlink: