Molecular group:
Cytokines and receptors
Molecule/Cell:
IRF-1/IL-12
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IRF-1 -/- + rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak
Additional phenotypes (EG vs Con):
Earlier death (days); no detectable NOS2 mRNA expression in brain or NO2- in serum; ↑ IFN-g production by ConA-stimulated spleen cells and in serum; ↑ IFN-g mRNA expression in brain, liver, spleen and kidney
Refs:
Tan et al., 1999, Infect Immun
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