IRF-1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IRF-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
IRF-1 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (40%)
Parasitemia (EG vs Con): 
Increased on day 7
Additional phenotypes (EG vs Con): 
Prolonged survival (until end of experiment day 13)
Refs: 
Senaldi et al., 1999, J Immunol