Molecular group:
Cytokines and receptors
Molecule/Cell:
IRF-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IRF-1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (40%)
Parasitemia (EG vs Con):
Increased on day 7
Additional phenotypes (EG vs Con):
Prolonged survival (until end of experiment day 13)
Refs:
Senaldi et al., 1999, J Immunol
Hyperlink: