IRF-1

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IRF-1
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
IRF-1 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
25% (at the end of observation day 23)
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Delayed onset and decreased peak
Additional phenotypes (EG vs Con): 
Prolonged survival (1-2 weeks); IL-10 mRNA was ↑ on day 4 and ↓ on day 11 after infection in liver and spleen and ↓ on day 8, 11 in the kidneys; TNF-a mRNA expression was undetectable throughout the course of infection
Refs: 
Tan et al., 2000, Parasite Immunol