Molecular group:
Cytokines and receptors
Molecule/Cell:
IRF-1
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IRF-1 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
25% (at the end of observation day 23)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); no detectable NOS2 mRNA expression in brain or NO2- in serum; ↓ IFN-g mRNA in liver, spleen and kidneys
Refs:
Tan et al., 1999, Infect Immun
Hyperlink: