Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-gRa
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
129P2Sv/Ev
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
IFN-gRa -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (60-100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ total leukocyte numbers and CD8+ T cells and similar numbers of macrophages, neutrophils and CD4+ T cells in the brain at the time of CM; ↑ numbers of total leukocytes, macrophages, CD4+ and CD8+ T cells and ↓ numbers of neutrophils in the lungs at the time of CM; no pulmonary edema; ↓ mRNA expression of MIP-1a/CCL3, RANTES/CCL5, IP-10/CXCL10, CCR2 and CCR1 and similar MCP-1/CCL2, CCR5 and CXCR3 in the brain; ↑ mRNA expression of MCP-1/CCL2 and IP-10/CXCL10, ↓ CCR2 and CXCR3 and similar MIP-1a/CCL3, RANTES/CCL5, CCR5 and CCR1 in the lungs; ↑ mRNA expression of MIP-1a/CCL3, IP-10/CXCL10, CCR5 and CXCR3 and similar MCP-1/CCL2, RANTES/CCL5, CCR2 and CCR1 in the spleen
Refs:
Belnoue et al., 2008, Parasite Immunol
Hyperlink: