Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-gR
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129/Sv/Ev x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
IFN-gR -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
Anemia
Pathology (EG):
Anemia
Parasitemia (EG vs Con):
Prolonged acute parasitemia with second peak
Additional phenotypes (EG vs Con):
Similar hypoglycaemia and weight loss; more pronounced hypothermia
Refs:
Li et al., 1999, Infect Immun
Hyperlink: