Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-gR
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
129/Sv/Ev x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
IFN-gR -/-
Lethal infection (Con):
no
Lethal infection (EG):
77%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Second peak as high as first peak
Additional phenotypes (EG vs Con):
First peak:↑ parasite-specific IgM, similar IgG1 and ↓ IgG2a, IgG2b and IgG3; ↓ serum NO3-; ↑ leukocytosis; similar anemia; ↓ splenomegaly; second peak: similar serum NO3-; ↑ leukocytosis and anemia; similar splenomegaly; ↑ parasite-specific IgM and IgG1 after second peak; resistant to secondary infection
Refs:
Favre et al., 1997, Parasite Immunol
Hyperlink: