Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-gR
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
DBA/1
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
IFN-gR -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (89%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ mRNA expression of chemokines (MCP-1, RANTES, MIP-1b, MIG, IP-10, I-TAC) and adhesion molecules (ICAM-1, LFA-1, P-selectin, VCAM-1), ↑ mRNA expression of P-selectin and abrogated IP-10 protein expression in the brain
Refs:
Van den Steen et al., 2008, Eur J Immunol
Hyperlink: