Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
N.I.
Mouse genetic background (Con):
SW
Experimental treatment group (EG):
rIFN-g
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak
Additional phenotypes (EG vs Con):
Prolonged survival (days, dose-dependent); ↑ phagocytic activity and H2O2 production by peritoneal macrophages that was partially abrogated after pretreatment with anti-IFN-g
Refs:
Shear et al., 1989, J Immunol
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