Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium berghei K173
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IFN-g -/-
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
No ↑ IDO and similar IL-10, IL-12 and IL-18 mRNA expression 24h p.i. in the spleen
Refs:
Mitchell et al., 2005, Infect Immun
Hyperlink: