Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
CBA/Ca
Experimental treatment group (EG):
anti-IFN-g
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (87,5%)
Pathology (EG):
CM (10-23,5%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); no neurological symptoms; no protection when administered just before onset of symptoms (day 7);↓ serum TNF-a; similar mononuclear cell infiltration in spleen and lymph nodes; no sequestration of macrophages, T cells or pRBC in the brain
Refs:
Grau et al., 1989, Proc Natl Acad Sci U S A
Hyperlink: