IFN-g/CTLA-4

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IFN-g/CTLA-4
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
IFN-g -/- + anti-CTLA-4
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
Moderate liver pathology
Pathology (EG): 
Moderate liver pathology
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
↓ serum AST and ALT levels compared to anti-CTLA-4-treated WT (similar compared to untreated WT mice); ↓ CD4+ T cells in liver compared to untreated and anti-CTLA-4-treated WT mice (similar compared to untreated IFN-g -/-)
Refs: 
Jacobs et al., 2004, Eur J Immunol