Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium berghei XAT
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Pure strain (100%)
Experimental treatment group (EG):
IFN-g -/-
Lethal infection (Con):
no
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
No parasite clearance
Additional phenotypes (EG vs Con):
↓ phagocytic activity by splenic macrophages; similar total IgG; ↓ IgG2a
Refs:
Yoneto et al., 2001, J Immunol
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