Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-g
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
IFN-g -/-
Lethal infection (Con):
no
Lethal infection (EG):
♂ 100 %; ♀ 40 %
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
♂: increased peak ♀: increased peak and increased recrudescences
Additional phenotypes (EG vs Con):
↓serum TNF-a, IL-12p70 and NO; ↓ splenic macrophages, NK cells and T cells (only in ♂); similar splenic B cells and Mac-1+ cells; ↓parasite-specific IgM, IgG2a, IgG3 and ↑IgG1; similar TNF-a, IL-4 and ↑ IL-10 production by spleen cells after in vitro stimulation with pRBC
Refs:
Su et al., 2000, Infect Immunol
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