IFN-b

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IFN-b
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^5
Mouse genetic background (Con): 
C57BL/6J
Experimental treatment group (EG): 
rIFN-b
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (80%)
Pathology (EG): 
CM (40%) (at the end of observation day 10)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
↓ BBB leakage, ↓ brain inflammatory cell infiltrates and improved vascular integrity 5 days p.i.; ↓ plasma MIG, TNF-a, IFNg, ↑ plasma IP-10 and similar plasma sICAM-1; ↓ MIG protein and ↑ IP-10 protein in the brain 5 days p.i.; ↓ MIG, ICAM-1 and ↑ IP-10 mRNA in the brain 5 days p.i.; ↓CD3+CD4+ and CD3+CD8+ T cells in the brain 6 days p.i.; ↓ T cells CXCR3 expression in the spleen 6 days p.i.; ↓ CXCR3 mRNA expression in the brain 6 days p.i.
Refs: 
Morell et al., 2011, Infect Immun