Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-b
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rIFN-b
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (40%) (at the end of observation day 10)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ BBB leakage, ↓ brain inflammatory cell infiltrates and improved vascular integrity 5 days p.i.; ↓ plasma MIG, TNF-a, IFNg, ↑ plasma IP-10 and similar plasma sICAM-1; ↓ MIG protein and ↑ IP-10 protein in the brain 5 days p.i.; ↓ MIG, ICAM-1 and ↑ IP-10 mRNA in the brain 5 days p.i.; ↓CD3+CD4+ and CD3+CD8+ T cells in the brain 6 days p.i.; ↓ T cells CXCR3 expression in the spleen 6 days p.i.; ↓ CXCR3 mRNA expression in the brain 6 days p.i.
Refs:
Morell et al., 2011, Infect Immun
Hyperlink: