Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-a/IFN-g
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rHu-IFN-a + anti- IFN-g
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased
Additional phenotypes (EG vs Con):
The inhibitory effect of IFN-a was partially abrogated
Refs:
Vigário et al., 2007, J Immunol
Hyperlink: