Molecular group:
Cytokines and receptors
Molecule/Cell:
IFN-a
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
rHu-IFN-a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (87%)
Pathology (EG):
CM (6%)
Parasitemia (EG vs Con):
Delayed onset and decreased
Additional phenotypes (EG vs Con):
Prolonged survival (~ 1 week): parasitemia increased when IFN-a treatment was abrogated; ↓ leukocytes in cerebral vessels and spleen; ↓ ICAM-1 in brain; ↓ serum TNF-a and↑ serum IFN-g; survival was prolonged by blood transfusion; ↓ reticulocytosis; similar anemia
Refs:
Vigário et al., 2007, J Immunol
Hyperlink: