Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-27R/IFN-g
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 9 generations
Experimental treatment group (EG):
IL-27R-/- (WSX-1 -/-) + anti-IFN-g
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
↑ Liver pathology
Parasitemia (EG vs Con):
Delayed
Additional phenotypes (EG vs Con):
↑ accumulation of CD4+ T cells in the liver
Refs:
Findlay et al., 2010, J immunol
Hyperlink: