IL-27R/IL-10

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-27R/IL-10
Plasmodium strain: 
Plasmodium berghei NK65
pRBC infection titer: 
10^4
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 9 generations
Experimental treatment group (EG): 
IL-27R-/- (WSX-1 -/-) + rIL-10
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
Liver pathology
Pathology (EG): 
↑ Liver pathology
Parasitemia (EG vs Con): 
Decreased
Additional phenotypes (EG vs Con): 
↑ accumulation of CD4+ T cells in the liver
Refs: 
Findlay et al., 2010, J immunol