IL-27R

Earlier death (~ 1 week) and ↑ weight loss; similar mRNA expression of TNF-a, IFN-g, IL-17A, IL-2, IL-10, IL-22, IL-23 and ↓ expression of IL-12p35 in the liver 7 days p.i.; ↑ mRNA expression of IFN-g, IL-12p35 and similar expression of TNF-a, IL-17A, IL-2, IL-10, IL-22 and IL-23 in the liver 14 days p.i.; ↑plasma IFN-g and IL-17A 14 days p.i.; similar proportions and total numbers of splenic CD4+ and CD8+ T cells 7 and 14 days p.i.; ↑ % of CD4+IFNg+ T cells and similar % of CD4+TNF-a+ and CD4+IL-17A+ T cells in spleen; ↑ IFN-g, similar IL-17A, TNF-a, TBET, RORc and ↓ IL-2, IL-10, IL-4, foxp3 and GATA3 mRNA expression by splenic CD4+ T cells; similar CD4+ T cells 7 days p.i. and similar frequency, numbers and activation status of CD8+ T cells 7 and 14 days p.i. in the liver; ↑ proportion, total number and activated CD4+ T cells in the liver 14 days p.i.; ↑ % of CD4+IFNg+ and CD4+TNF-a+ T cells and similar % of CD4+IL-17A+ T cells in liver; ↑ IFN-g, similar IL-17A, TNF-a, IL-2, foxp3, TBET, GATA3, RORc and ↓ IL-10 and IL-4 mRNA expression by liver CD4+ T cells 14 days p.i.;