Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-18
Plasmodium strain:
Plasmodium yoelii 265
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
rIL-18
Lethal infection (Con):
20%
Lethal infection (EG):
0-20% (dose-dependent)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak (dose-dependent)
Additional phenotypes (EG vs Con):
Dose-dependant survival due to ↑ serum IFN-g production; ↓ liver and spleen pathology
Refs:
Singh et al., 2002, J Immunol
Hyperlink: