IL-18

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-18
Plasmodium strain: 
Plasmodium berghei NK65
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 8 generations
Experimental treatment group (EG): 
IL-18 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
Liver pathology
Pathology (EG): 
Liver pathology
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar GPT (ALT) serum levels and liver injury
Refs: 
Adachi et al., 2001, J Immunol