Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-18
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
IL-18 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar GPT (ALT) serum levels and liver injury
Refs:
Adachi et al., 2001, J Immunol
Hyperlink: