Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-15
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IL-15 -/-
Lethal infection (Con):
no
Lethal infection (EG):
10%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased and persistent low parasitemia
Additional phenotypes (EG vs Con):
↓serum IFN-g, TNF-a, IL-12p70 and similar IL-10; ↑ number of apoptotic NK cells 5 days p.i.; ↓ NK cell cytotoxicity and in vitro IFN-g production; ↓ parasite-specific total IgG, IgG1, IgG2a, IgG2b, IgG3 and IgM
Refs:
Ing et al., 2005, Infect Immun
Hyperlink: