Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12p40
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-IL-12p40
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (~ 1 week); ↓serum AST and ALT; ↓ liver injury; ↓ in vitro production of IFN-g by spleen and liver cells
Refs:
Yoshimoto et al., 1998, J Immunol
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