Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12/chloroquine
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
rIL-12 + chloroquine
Lethal infection (Con):
yes
Lethal infection (EG):
no
Pathology (Con):
Severe anemia
Pathology (EG):
None
Parasitemia (EG vs Con):
Decreased peak
Additional phenotypes (EG vs Con):
↓ anemia, ↑ erythropoiesis and reticulocytosis; combined therapy induced ↑ IFN-g production by parasite antigen stimulated splenocytes; resistant to secondary infection due to ↑ parasite-specific IgG levels
Refs:
Mohan et al., 1999, Infect Immun
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