Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12/IFN-g/TNF-a
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
rIL-12 + anti-IFN-g + anti-TNF-a
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed peak (days) and increased recrudescences
Additional phenotypes (EG vs Con):
N.I.
Refs:
Stevenson et al., 1995, J Immunol
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