Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium berghei XAT
pRBC infection titer:
10^4
Mouse genetic background (Con):
CBA/JNCrj
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and no second peak
Additional phenotypes (EG vs Con):
↑ IFN-g and IL-10 and ↓ IL-4 mRNA expression in the spleen; ↑ IFN-g production by unstimulated, ConA and anti-CD3 stimulated spleen cells; ↓ IL-4 production by ConA and anti-CD3 stimulated spleen cells
Refs:
Yoshimoto et al., 1998, J Infect Dis
Hyperlink: