Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Severe anemia
Pathology (EG):
Severe anemia
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar anemia and reticulocytosis; rIL-12-treated splenocytes produced similar amounts of IFN-g after parasite-antigen stimulation compared to untreated splenocytes
Refs:
Mohan et al., 1999, Infect Immun
Hyperlink: