Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
25%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased peak and spontaneous decline
Additional phenotypes (EG vs Con):
Dose-dependant survival; ↑ production of IFN-g and similar production of IL-4 and IL-5 by spleen cells 7 days p.i.; ↑ serum IFN-g, TNF-a and NO3-
Refs:
Stevenson et al., 1995, J Immunol
Hyperlink: