Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
A/J
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Spontaneous decline
Additional phenotypes (EG vs Con):
↑ NKCC by spleen cells (maximal NKCC activity enhancement after 2 days rIL-12 treatment and ↓ NKCC activity enhancement after longer rIL-12 treatment); ↑ splenic cellularity (similar to infected C57BL/6 mice): ↑ number of CD3+, B220+ and Mac-1+ spleen cells; ↑ IFN-g and similar TNF-a production by splenic NK cells
Refs:
Mohan et al., 1997, J Immunol
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