Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
rIL-12
Lethal infection (Con):
yes
Lethal infection (EG):
20% (at the end of observation day 23)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset and decreased peak which declined partly with subsequent increase
Additional phenotypes (EG vs Con):
Prolonged survival (1-2 weeks); IL-10 mRNA was ↓ on day 11 after infection in liver and spleen and ↓ on day 8, 11 in the kidneys; similar TNF-a expression in liver, spleen and kidneys
Refs:
Tan et al., 2000, Parasite Immunology
Hyperlink: