Molecular group:
Cytokines and receptors
Molecule/Cell:
IL-12/CTLA-4
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
IL-12p40 -/- + anti-CTLA-4
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Moderate liver pathology
Pathology (EG):
Moderate liver pathology
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↓ serum AST and ALT levels compared to anti-CTLA-4-treated WT (similar compared to untreated WT mice); ↓ CD4+ T cells in liver compared to anti-CTLA-4-treated WT mice (similar compared to IL-12 -/- and untreated WT mice)
Refs:
Jacobs et al., 2004, Eur J Immunol
Hyperlink: